View Alexandrescu Structure Gallery

Link to Alexandrescu Lab Structures in the PDB

We're going to start using this space to post our latest BioRxiv preprints (marked in purple). It takes so long to go through the journal system. Might as well post them here in the meantime.

90) Harris, R.E., Whitehead III, R.D. & Alexandrescu A. T. (2024) “Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein-binding zinc-fingers", BioRxiv preprint ->

https://doi.org/10.1101/2024.12.10.627839

NMR studies of a highly aggregation-prone zinc finger promoted us to look for sequence properties that could distinguish dsDNA-binding zinc fingers from those with protein-binding functions.

88) Woodbury, B.M., Newcomer, R.L., Alexandrescu, A.T. & Teschke C.M. (2024) “Templated trimerization of phage L decoration protein on capsids.", BioRxiv preprint ->

https://doi.org/10.1101/2024.09.08.611893

As an on-again, off-again protein folder, I have to say this has been one of the weirdest proteins in terms of folding I've ever worked with in collaboration with the Teschke lab. It just kept puzzling us for over 4 years!

87) Rua A.J, Mitchell, W., Claypool, S.M., Alder, N.N.  & Alexandrescu, A.T. (2024) “Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An in-organello real-time NMR study”, J Biol Chem, in press.

10.1016/j.jbc.2024.107746

A collaboration with the Alder lab where we use NMR to follow metabolism ... inside viable mitochondria, with or without mutations corresponding to a mitochondrial genetic disease.